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KMID : 0350519950480030755
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Journal of Catholic Medical College
1995 Volume.48 No. 3 p.755 ~ p.765
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The 5-Year Survival According to Dukes' Stage, p-53 Protein Expression and DNA Ploid I Mid-rectal -Adenocarcinoma Patients
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Abstract
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Transformation-related protein designated as p53 has been recently detected in a range of neoplastic cells including colon carcinoma by using monoclonal antibody to P-53, and DNA analysis by using flowcytometry.
The purpose of this study was to investigate the expression of p-53 and DAN ploid and the 5-year survival rates according to Dukes'stage, p-53 protein expression and DNA ploid in mid-rectal adenocarcinoma patients.
Fifty-nine specimens, including 29 specimens with mid-rectal adenocarcinoma that underwent anterior resection and 30 specimens with mid-rectal adenocarcinoma that underwent abdominoperineal resection from January 1980 in St. Mary's Hospital of
Catholic
University Medical College, were included in this study.
The paraffin embedded tissue sections were used for detection of p-53 protein by using monoclonal antibody and DAN ploid by using flowcytometry.
@ES The results were as follows :
@EN 1. Over all 5-year survival rate of 59 patients with mid-rectal adenocarcinoma that underwent surgery, was 40.7% and the differences of survival rates according to Dukes' stage are significant. The 5-year survival rate of 29 patients that
underwent
anterior resection was 41.4% and those that underwent abdominoperineal resection was 40.0%, respectively. The difference between two groups was not significant.
2. The 5-year survival rate of 30 patients with p-53 positive reactions was 40.0% and 29 patients with p-53 negative reactions was 41.4%. The difference between the two groups was not significant.
3. The ratio of patients with metastatic lymph nodes that showed p-53 positive reactions, was 70.0% and that of patients with metastatic lymph nodes that showed p-53 negative reactions, was 48.8% respectively. Although rate of lymph node
metastasis was
higher in the p-53 positive group, the difference between the two groups was not significant.
4. The 5-year survival rate of the 32 patients with DNA diploid was 40.6% and the 27 patients with DNA aneuploid was 40.7%. The difference between the two groups was not significant.
5. The rato of patients with DNA diploid, that had metastatic lymph node, was 46.9% and 27 patients with DNA and that of patients with DNA aneuploid, that had metastatic lymph node, was 74.1% respectively. The rate of lymph node metastasis was
higher
in DNA aneuploid group and the difference between tow groups was significant.
Above results suggest that patients that showed p-53 positive reactions had higher rate of lymph node metastasis than those that showed p-53 negative reactions and DNA aneuploid was important in lymph node metastasis. But thers was no
relationship
p-53
expression, DNA ploid and 5-year survival rate.
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KEYWORD
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